My training as a medical doctor began in India, where I was witness to unfortunate cases of birth asphyxia, and the consequent long-term neurological complications. This left a lasting impression on me and influenced my decision to pursue a career in academic pediatrics, and subsequently, neonatology.
Currently, my work is focused on studying the effect of gas exchange on pulmonary and systemic hemodynamics in both preterm and term models during and after resuscitation. As a junior faculty at the State University of New York at Buffalo, I have evaluated the effect of placental transfusion during preterm resuscitation. In the future, I intend to explore the combined impact of oxygen use and placental transfusion during preterm resuscitation. Click here to view my published work.
As a researcher, my focus is on improving our understanding of physiologic changes at birth and delivery room stabilization. My goal is to generate the quality evidence needed to improve our treatment of preterm and term newborns.
Advocating for our most vulnerable patients
Despite being a neonatologist, I felt completely unprepared as a father when I had a son who was born early. I stood in disbelief as he needed stabilization. Thankfully, he did not require cardiopulmonary resuscitation, and we were in the company of trusted colleagues. As a scientist, I had personally evaluated both umbilical cord milking and delayed cord clamping, so it was reassuring to witness these procedures being put into practice with my new family.
Being in the delivery room as father has completely changed my perspective as a doctor. I have a renewed understanding of the complexity of premature birth, and a passion to pursue research to protect other children, like my own son. In most fields of medicine, evidence based care is the mechanism of change when instituting new therapies. This is a challenge in the field of neonatology. Parents assume that their newborn is receiving tried and proven care. On the contrary, the interventions we utilize need scrutiny, and refinement. Having access to in-vivo animal models is a safe way to evaluate, and validate the therapeutic interventions used in neonatal practice.
The use of 10x genomics to study the effect on progenitor cells after delayed cord clamping and oxygen exposure in a preterm ovine model- a pilot study
The utility of monitoring cerebral regional oxygen saturation during resuscitation in an asphyxiated preterm lamb model
Effect of various inspired oxygen concentrations on pulmonary and systemic hemodynamics and oxygenation during resuscitation in a transitioning preterm model
Is heart rate of 60/min the optimal cut-off for initiating chest compressions? -Characteristics of coronary blood flow during asphyxia and neonatal resuscitation
Epinephrine vs. vasopressin in an ovine model of cardiac arrest- differences in return of spontaneous circulation, pharmacokinetics and vasoreactivity
Randomized trial of 0.01, 0.03 and 0.1mg/kg of epinephrine for cardiac arrest by umbilical cord occlusion in lambsThe utility of monitoring cerebral oxygen saturation during resuscitation in an asphyxiated preterm lamb model
Predictors to stop neonatal resuscitation after cardiac arrest
Factors associated with use, survival and neurodevelopment outcome following inhaled nitric oxide exposure in extremely preterm infants
Use of inhaled nitric oxide in the neonatal research network
Early hypoxemic respiratory failure in extremely preterm neonates: Characteristics, mortality, and neurodevelopmental outcomes
Areas of Practice
The Division of Neonatology expends substantial effort in both clinical and basic science research and enjoys international recognition for its work related to pulmonary vascular biology, and premature lung disease and lung development.
Historically, our laboratory was influential in developing surfactant treatment, nitric oxide therapy, and early hydrocortisone treatment for prevention of bronchopulmonary dysplasia. These therapies were first proven safe and effective by utilizing our in vivo ovine model.
Comprised of a team of neonatologists along with nursing and other clinical staff specializing in the critical care of newborns, the Neonatal Intensive Care Unit serves Buffalo and Western New York and the surrounding regions. The 64-bed mostly private room NICU admits over 850 babies each year and has an average daily census of 52 babies.
Our faculty members conduct a weekly series of seminars on developmental biology of the fetus and neonate, research design and methods, biochemistry and pathophysiology.
In addition to these didactic clinical and basic science lectures, we hold a biweekly clinical neonatology fellows’ case conference and monthly journal club, journal watch, pulmonary biology research seminar series, obstetrics-gynecology, QA/pathology and ethics conferences.